Skip to main content

MBG 407 - Cancer Biology

Faculty of Engineering and Natural Sciences · Molecular Biology and Genetics (English 30%) · Undergraduate

ECTS: 5 T+P+L: 3+0+0 Compulsory
Coordinator: Dr. Öğr. Üyesi Mehmetali TİBATAN

Course Objective

The aim of the Cancer Biology course is to explain, convey, support with resources, and teach the following:

  • The characteristic features of cancer cells,
  • The development and order of cancer development and metastatic stages,
  • The concepts of oncogenes and oncoproteins that cause cancer,
  • The tumor microenvironment and its role in cancer development,
  • Genomic instability and oncogenic activation relation
  • The difference between stem cells and cancer stem cells,
  • The definition of angiogenesis and its importance for cancer development,
  • The difference between benign and malignant tumors,
  • Effect of anti-apoptotic pathways in cancer cells
  • The available treatment approaches against cancer.

Course Content

This course covers the nature of cancer, cancer development, genetics, causes of cancer, genetic changes in cancer, oncogenes, tumor suppressor genes, apoptosis, and metastasis. It also includes information on the molecular mechanisms of cancer and how cancer cells behave differently from normal cells. Cancer stages and developmental phases in cancer cells are examined.

Required Resources

Weinberg, R. A., & Weinberg, R. A. (2006). The biology of cancer. WW Norton & Company.

Rules

All students are required to attend 70% of the theoretical lectures.
The passing grade for the course is 50 points.
The allowed time for being late to class is the first 10 minutes.
The allowed time for being late to the exam is 20 minutes.
If anyone leaves the exam within the first 20 minutes, late students will not be admitted regardless of the 20-minute time tolerance.
Non-class activities (playing games, making phone calls, phone texting, consuming strongly scented foods such as spices, garlic, and onions, personal care, etc.) are prohibited during class.

Course Learning Outcomes

  1. Student explains the basic concepts of cancer formation and development.
  2. Explains the roles of oncogenes and oncoproteins involved in cancer development.
  3. Understands the difference between cancer biology and cancer molecular biology
  4. Can understand the precursor signaling pathways in cancer cell development.
  5. Can explain the stages of cancer development and how these stages can be prevented.
  6. Understands the description of important markers in cancer molecular mechanisms and their mechanisms of emergence.
  7. Understands the concepts of apoptosis and anti-apoptosis
  8. Explains the importance of the anti-apoptosis mechanism for cancer
  9. Gains knowledge about the stages of angiogenesis
  10. Understands the metastatic stages in malignant tumors
  11. Understands the differences between stem cells and cancer stem cells.
  12. Learns the necessary conditions for secondary tumor formation.
  13. Knows the difference between intravasation and extravasation.

Core Area Distribution

(44) Physical Sciences%50 (72) Health%50

Teaching Methods

ExpressionQuestion-AnswerDiscussion

Assessment & Evaluation

Testing (Essay / Tests: True-Falls, multiple-choice, short answer, matching)

ECTS / Workload

ActivityQuantityDuration (h)Total Workload
Course Duration (Including Exam Week)16348
Out of Class Study Period16348
Midterm122
Quiz000
Assignment21326
Practice000
Final122

Course Schedule

WeekSubjectPreparation
1Introduction to cancer biology and course.Course content will be shared.
2Cancer Biology: General ConceptsCourse content will be shared
36 hallmarks of cancerCourse content will be shared
410 hallmarks of cancerCourse content will be shared.
5Molecular mechanism of cancerCourse content will be shared.
6Molecular mechanism of cancerCourse content will be shared
7MidtermMidterm
8Energy metabolism in cancer and Warburg EffectCourse content
9Adhesion in cancer cells and regulation of ECMCourse content will be shared
10Adhesion in cancer cells and regulation of ECMCourse content will be shared
11Invasion and metastasisCourse content will be shared
12AngiogenesisCourse content will be shared
13Concept of cancer stem cellCourse content will be shared
14Exercise for the final examCourse content will be shared
15RevisionRevision
16FinalFinal